Foxa2 is required for transition to air breathing at birth
نویسندگان
چکیده
منابع مشابه
Foxa2 is required for transition to air breathing at birth.
Toward the end of gestation in mammals, the fetal lung undergoes a process of differentiation that is required for transition to air breathing at birth. Respiratory epithelial cells synthesize the surfactant proteins and lipids that together form the pulmonary surfactant complex necessary for lung function. Failure of this process causes respiratory distress syndrome, a leading cause of perinat...
متن کاملFrom liquid to air: breathing after birth.
Studying the transition from placental to pulmonary gas exchange has always been an intriguing and difficult challenge. Lung liquid is partly cleared before and during labour, but residual liquid must be cleared after birth. Where the liquid goes at the moment air is drawn into the lungs is unclear, but recent evidence indicates that it is transiently retained within the interstitial tissue cau...
متن کاملGeminin is required for epithelial to mesenchymal transition at gastrulation.
Geminin is a multifunctional protein previously suggested to both maintain the bone morphogenetic protein inhibition required for neural induction and to control cell-cycle progression and cell fate in the early embryo. Since Geminin is required in the blastocyst on E3.5, we employed shRNA to examine its role during postimplantation development. Geminin knockdown inhibited the epithelial to mes...
متن کاملLPCAT1 regulates surfactant phospholipid synthesis and is required for transitioning to air breathing in mice.
Respiratory distress syndrome (RDS), which is the leading cause of death in premature infants, is caused by surfactant deficiency. The most critical and abundant phospholipid in pulmonary surfactant is saturated phosphatidylcholine (SatPC), which is synthesized in alveolar type II cells de novo or by the deacylation-reacylation of existing phosphatidylcholine species. We recently cloned and par...
متن کاملLymphatic function is required prenatally for lung inflation at birth
Mammals must inflate their lungs and breathe within minutes of birth to survive. A key regulator of neonatal lung inflation is pulmonary surfactant, a lipoprotein complex which increases lung compliance by reducing alveolar surface tension (Morgan, 1971). Whether other developmental processes also alter lung mechanics in preparation for birth is unknown. We identify prenatal lymphatic function ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2004
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0404424101